Program

13 October, Rīga Stradiņš University 16 Dzirciema street, Great Hall

8:30-9:00Registration and networking  
9:00-10:00

Opening

Agrita Kiopa (Latvia), Elīna Dimiņa (Latvia)


Recording

Aigars Pētersons, Rector of Rīga Stradiņš University
John M. Tully, PMNET mentor
Daniels Pavļuts, Minister of Health of the Republic of Latvia
Raimonds Lapiņš, Deputy State Secretary on Economic Development, Ministry of Economics
Fulvia Raffaelli, DG SANTE Head of Digital Health Unit
Patient experience
10:00-10:30Break for refreshments and networking 
10:30-12:30

Cancer genetics and precision medicine


Recording

Sandra Lejniece (Latvia)
Rob Pieters  (The Netherlands)
10:30-10:45Rob PietersChief Medical Officer (CMO) at Princess Máxima Center for Pediatric Oncology and Professor of Pediatric Oncology at the University of Utrecht (The Netherlands)
Precision Medicine in the Princess Máxima Center for Pediatric Oncology
10:45-11:00David Gisselsson Nord, Division of Clinical Genetics; Principal investigator at LUCC: Lund University Cancer Centre (Sweden)Implementing nationwide whole genome sequencing for all children with cancer in Sweden
11:00-11:15Alwin Krämer, Full Professor at the University of Heidelberg, Director of the Clinical Cooperation Unit Molecular Hematology/Oncology of German Cancer Research Center (DKFZ), Department of Internal Medicine, University of Heidelberg (Germany)Precision oncology approaches in cancer of unknown primary (CUP) 
11:15-11:30Martin Zoche, director at Molecular Tumor Profiling,  Dept. of Pathology and Molecular Pathology, University Hospital Zurich and a Lecturer at the University of Zurich (Switzerland) Homologous Recombination Deficiency (HRD) Testing in Clinical Practice
11:30-11:45 Juha Kononen, Chief Clinical Director, Docrates Cancer Clinic (Finland)
Precision oncology in clinical practice: successes and challenges
11:45-12:00Jukka Kanerva,  Consultant in pediatric hematology and oncology, New Children’s Hospital, Helsinki University Hospital and University of Helsinki (Finland)
Pediatric precision medicine at Helsinki University Hospital
12:00-12:30Q&A 
12:30-13:30Lunch & Networking &  Satellite symposia by Roche (see below) 
13:00-13:30 Satellite symposia by Roche
Prof. Marius Žemaitis
, Lithuanian University of Health Sciences Hospital, Kaunas Clinic, Head of Chest Oncology and Interventional Pulmonology Sector (Lithuania)

Recording

CGP in oncology - benefits for clinicians and patients

More info on topic

13:30-15:10

National diagnostics capacity - possibilities and challenges 


Recording

Gunta Purkalne (Latvia)
Karolis Šablauskas (Lithuania)
13:30-13:45  Linda Gailīte, PhD, Head of the Laboratory, Leading Researcher, Scientific Laboratory of Molecular Genetics, Rīga Stradiņš University (Latvia)
Overview of genetic analysis methods used clinical medicine 
13:45-14:00 Ģirts Šķenders, Riga East clinical university hospital , Laboratory Service (Latvia)Possibilities and challenges in molecular pathology at REUH
14:00-14:10 Inta Liepniece Karale, Associate Professor  at Rīga Stradiņš UniversityDepartment of Pathology, Pathologist at Riga East clinical university hospital, Laboratory Service  (Latvia)
Molecular pathology at REUH "Pathology Center"
14:10-14:20  Dmitrijs Rots, Molecular geneticist, Children's Clinical university hospital (CCUH) (Latvia)
Pediatric cancer molecular testing specifics and CCUH approach
14:20-14:30  Egija Berga-Švītiņa and Anna Janberga, Molecular geneticist, Children's Clinical university hospital (Latvia)
Molecular testing of pediatric cancers: CCUH case examples.
14:30-14:45Anna Valaine, Hematooncologist,  Children's Clinical university hospital (Latvia) Precision medicine for pediatric cancer patient - hematooncologists perspective
14:45-15:00 Gunta Purkalne, PhD, MD, Professor at Rīga Stradiņš University, leading researcher at Department of Internal Medicine (Latvia) Medical Oncology - at the frontline of utilizing personalized medicine
15:00-15:10Q&AChallenges and next steps 
15:10-15:40 Break for refreshments and networking  
15:40-17:30 

Precision medicine and biobanking


Recording

Jānis Kloviņš (Latvia)
Lars O. Baumbusch (Norway)
15:40-15:55 Lars O. Baumbusch, Senior scientist at Department of Pediatric Research, Division of  Paediatric and Adolescent Medicine, Oslo University Hospital (Norway) The Norwegian Childhood Cancer Biobank - experiences and future perspectives 
15:55-16:10 Johanna Sandgren, PhD, director of the Swedish Childhood Tumour Biobank, Karolinska Institutet (Sweden)

The Swedish Childhood Tumor Biobank: A national sample collection and genomic characterization initiative of pediatric solid tumors for research purpose

16:10-16:30Jānis Kloviņš, Chairman of the Scientific Council of the Latvian Biomedical Research and Study Centre, Senior Researcher of the Latvian Biomedical Research and Study Centre, and Professor of Molecular Biology at the University of Latvia (Latvia)Biobank and Latvian Pediatric Cancer Initiative - project results
16:30-16:45Eero Punkka, Director at Helsinki Biobank (Finland)The use of genomic biobank data in the personalized and preventive healthcare of biobank participants. 
16:45-17:00 Peeter Padrik, Associate Professor of Oncology at University of Tartu, medical oncologist, scientist and healthcare entrepreneur (Estonia)
Implementation of polygenic risk scores for personalized cancer prevention
17:00-17:15 Ilmārs Stonāns, Deputy Director at Institute of Clinical and Preventive Medicine, University of Latvia (Latvia)
The experience of Cancer biobanking at the Institute of Clinical and Preventive Medicine, University of Latvia and Riga East University Hospital
17:15-17:30  Q&A and Discussion 
17:30 Closing of Day I 

Parallel Sessions, Hall Senates

Workshops with Google

 
10:30-11:30Next generation approach to precision medicine Cristian Mezzanotte  
11:30- 12:00DemoCristian Mezzanotte
12:00-13:00Break 
13:00-13:30 Networking and Start-Up presentations  
13:30- 15:10 Leveraging Applied Innovation design thinking - workshopJolanta Kruceliene, Cristian Mezzanotte
13:30-14:00 Fundamental shift from “Healthcare” to “Health”  
14:00- 14:30 Applied Innovation Framework   
14:30 - 15:10   Ideation  


15:30-17:30

Roundtable on Education and competences

Recording

Moderated by: Juris Šteinbergs
 Baiba Vilne, Head of Bioinformatics Lab, Rīga Stradiņš university (Latvia)  Karīna Siliņa, SNF Prima group leader, ETH Zurich, Department of Chemistry and Applied Biosciences, Institute of Pharmaceutical Sciences (Swithzerland) Martin Zoche, Director Molecular Tumor Profiling, Department of Pathology and Molecular Pathology University Hospital Zurich (Switzerland), Nils Rostoks,  full professor at University of Latvia, Faculty of Biology (Latvia) Jānis Liepiņš, University of Latvia | LU · Institute of Microbiology and Biotechnology Doctor of Philosophy (Latvia) Terry Vrijenhoek, Staff and Faculty Advisor | Department of Genetics | University Medical Centre Utrecht (The Netherlands) 

14 October, Rīga Stradiņš University 16 Dzirciema street, Great Hall


8:00-8:30Networking 
8:30-9:30

Molecular tumor boards (MTB) - support for clinical decision making and education


Recording

Martin Zoche (Switzerland)
Valts Ābols (Latvia)
8:30-8:45Martin Zoche, Director Molecular Tumor Profiling, Department of Pathology and Molecular Pathology University Hospital Zurich (Switzerland) Molecular Tumor Boards supports Clinical Decisions  
8:45-9:00Ed Schuuring, Full Professor in Molecular Oncological Pathology, University Medical Center Groningen  (The Netherlands)The Dutch experience using predictive profiling to guide targeted therapy in cancer patients: the role of our Molecular Tumor Board
9:00-9:15 Karolis Šablauskas, Hematologist, Hematology, Oncology and Transfusion Medicine Center Vilnius University Hospital Santaros Klinikos (Lithuania)
Personalizing treatment of acute myeloid leukemia, experience of Vilnius University Hospital Santaros Klinikos
9:15-9:25  Q&A  
9:25-10:20

Systematic implementation of precision medicine 

Recording

Alinta Hegmane (Latvia)
Mārcis Leja (Latvia)
9:25-9:40Katarina Puco, senior consultant oncologist working at Oslo University Hospital, Institute of Cancer Research as a study oncologist in IMPRESS- Norway study (Norway)Implementing Precision Medicine in Norway - IMPRESS Norway trial
9:40-9:55Vilja Pietiäinen, Team leader and senior scientist at the Institute for Molecular Medicine Finland (FIMM, HiLIFE, University of Helsinki) (Finland) Functional precision medicine for solid tumors
9:55-10:10Richard Rosenquist Brandell, Professor of Clinical Genetics at the Department of Molecular Medicine and Surgery, Karolinska Institutet and Senior Physician in Clinical Genetics at Karolinska University Hospital (Sweden) Genomic Medicine Sweden - implementing precision medicine in a regionally organized healthcare system
10:10-10:25

Thomas Hofmarcher, Research Director at IHE - The Swedish Institute for Health Economics (Sweden)

The Value of Precision Medicine in Oncology – the Case of Non-Small Cell Lung Cancer
10:25-10:35 Q&A and Discussion  
10:35-10:50Break for refreshments and networking  
10:50-11:10Denis Horgan, Chair, ICGC ARGO Independent Advisory Committee at International Cancer Genome Consortium; Executive Director, European Alliance for Personalised Medicine (Belgium)

Recording

Identifying the Steps Required to Effectively Implement Advanced Molecular Diagnostic in Oncology at a National Level in Europe: A policy perspective
  Advanced molecular Diagnostics  may enable more focused and highly personalized cancer treatment, with the National Comprehensive Cancer Network and European Society for Medical Oncology guidelines now recommending NGS for daily clinical practice for several tumor types. However, NGS implementation, and therefore patient access, varies across Europe; a multi-stakeholder collaboration is needed to establish the conditions required to improve this discrepancy.  The main challenges identified relate to the demand for NGS tests (governance, clinical standardization, and awareness and education) and supply of tests (equitable reimbursement, infrastructure for conducting and validating tests, and testing access driven by evidence generation). Recommendations made to resolve each of these challenges should aid multi-stakeholder collaboration between national and European initiatives, to complement, support, and mutually reinforce efforts to improve patient care.
11:10-12:00

Roundtable with main healthcare sector stakeholders 


Recording

MoH, NHS

Presentation from: Ruslan Baltaga, MD, PhD, EDAIC. Director Oncologic Institute Chisinau.  (Moldova)
12:00-13:00Lunch & Networking 
13:00-14:00 

Shaping the future of research through healthcare data

Recording

Emil Syundyukov (Latvia)
13:00-13:15 Janek Metsallik, Digital Health Interoperability, Tallinn University of Technology (Estonia) Approaches to secondary use of data from Saudi-Arabia and Estonia  
13:15-13:30 Mārcis Leja,  Professor of Medicine, Director of the Institute of Clinical and Preventive Medicine, University of Latvia, Head of the Dept. of Research, Riga East University hospital (Latvia)Data collaborative on gastric cancer
13:30-13:45Niklas  Probul, doctoral researcher, Institute for Computational Systems Biology at the University of Hamburg (Germany)Privacy-Aware Microbiome Profiling for Colorectal Cancer Detection using Federated Learning'
13:45-14:00 Q&A 
14:00-14:15 Break for refreshments and networking  
14:15-15:15

Joint session with the Ministry of Economics of the Republic of Latvia and the Investment and Development Agency of Latvia


Bioinformatics and Big Data for Precision Medicine

About the discussion:

Big data companies, IT sector and state institutions will discuss ethical, technical and economical aspects in building current data infrastructure for precision medicine in Latvia.


Recording


Moderator: 
Dāvids Fridmanis, PhD Senior Researcher Latvian Biomedical Research and Study Centre
Participants
  • Janek Metsallik, Digital Health Architect, Estonia
  • Lauris Cikovskis, Head of HPC center, Riga Technical University
  • Renāte Strazdiņa, Customer Transformation and Innovation for Healthcare and Lifescience Lead EMEA at Microsoft
  • Jānis Kloviņš, Head of the Scientific Council, Latvian Biomedical Research and Study Center
  • Raimonds Osis, Head of Legal Unit, Health Management Lecturer Group, Rīga Stradiņš university
  • Cristian Mezzanotte,  Customer Engineer, Google Cloud Public Sector

Presentations from: 

Aleksandrs Mārtiņš Blūms, Counsellor for Research and Space, Permanent Representation of the Republic of Latvia to the European Union.

15:20-16:00Closing  
15:20-15:35 

Final remarks from round-table and panel discussions


Recording

  • Raimonds Lapiņš, Deputy State Secretary on Economic Development, Business Competitiveness, and Innovation of the Ministry of Economics of Latvia
  • Gatis Ozols, Deputy State Secretary on Digital Transformation issues,  Ministry of Environmental Protection and Regional Development
  • Aiga Balode, Deputy State Secretary, Ministry of Health of the Republic of Latvia.
15:35-15:50Baiba Ziemele, Chairwoman of the Board, 
Chairwoman of the Board
Patient's Perspective 
15:50-16:00 Closing remarks 


Parallel Sessions, Hall Senates


9:20-10:30

Joint session with the Ministry of Economics of the Republic of Latvia and the Investment and Development Agency of Latvia

Mission-oriented approach for precision medicine evolution


More info


Recording

Moderator

Denis Horgan

Executive Director from the European Alliance of Personalised Medicine (EAPM)

Participants

  • Raimonds Lapiņš, Deputy State Secretary on Economic Development, Business Competitiveness, and Innovation of the Ministry of Economics of Latvia
  • Alvils Krams,  Professor at University of Latvia, Chief Specialist in Pneumonology, Riga East University Hospital, Latvia

10:30-11:10Presentations in Great Hall 
11:10-12:00 Presentation & Workshop  with the Ministry of Economics of the Republic of Latvia and the Investment and Development Agency of Latvia

Leveling up Biomedicine Ecosystem


More info


Recording

Moderator

Ieva Siliņa - Adviser to the Minister of Economics Ieva is also External Science and Education Policy Adviser to the President of Latvia and Former leader of Association of Latvian Young Scientists

Participants

  • Agrita Kiopa - Vice-Rector for Science, Rīga Stradiņš University
  • Raimonds Lapiņš - Deputy State Secretary on Economic Development, Business Competitiveness, and Innovation of the Ministry of Economics of Latvia
  • Terje Peetso - Member of the management board at the North Estonia Medical Centre
  • Lauma Muižniece - Director of Latvian Council of Science, Latvia CERN ILO, Assistant professor

Presentation by Dace Dimza-Jones, Deputy Head of Northern Powerhouse Life Sciences: Biotechnology & Pharmaceuticals Department for International Trade. Former Industry Facilitator at NIHR. Clinical Research Network Greater Manchester.

12:00-13:00Lunch & Networking  
13:00-14:00

Scientific session 
Scientific activities and projects


Recording

Una Riekstiņa (Latvia)
Zanda Daneberga (Latvia)
13:00-13:10 Kārlis Pleiko, researcher at the University of Latvia (Latvia) Aptamers targeting carcinoma cell surface receptors
13:10-13:20Katrina Daila Neiburga, Rīga Stradiņš University (Latvia)RNA-seq in the molecular diagnosis of primary immunodeficiencies (PID)
13:20-13:30Ērika Bitiņa-Barlote, Rīga Stradiņš University (Latvia)Biomarkers for early diagnosis of bladder tumor
13:30-13:40Nora Kriķe,  Rīga Stradiņš University (Latvia)Copy number variation and BRCA1/2 inactivation in breast cancer tissues
13:40-13:50Maksims Ivanovs, researcher at Institute of Electronics and Computer Science (Latvia)AI-assisted identification of precancerous gastric lesions
13:50-14:00  Q & A